Significance of cyclooxygenase-2 in oncogenesis
نویسندگان
چکیده
منابع مشابه
Clinical significance of cyclooxygenase-2 (COX-2) in multiple myeloma.
Several biological and clinical considerations suggest the involvement of cyclooxygenase-2 (COX-2), the key enzyme of prostaglandin (PG) synthesis, in the pathogenesis and progression of haematological malignancies. Despite the wealth of data concerning COX-2 expression, only limited information is available on multiple myeloma (MM). Using standard immunohistochemistry we therefore evaluated CO...
متن کاملPrognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma.
PURPOSE To determine the relative prognostic significance of cyclooxygenase (COX)-2 expression in patients with oropharyngeal squamous cell carcinoma (SCC). EXPERIMENTAL DESIGN This retrospective cohort study included 82 patients with SCC referred to the Department of Therapeutic Radiology at Yale-New Haven Hospital (Connecticut) between 1980 and 1999 who were treated with primary external be...
متن کاملPrognostic significance of elevated cyclooxygenase-2 expression in breast cancer.
Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast cancers. Moderate to strong (elevated) expression of Cox-2 protein was observed i...
متن کاملPrognostic significance of cyclooxygenase-2 overexpression in glottic cancer.
PURPOSE Cyclooxygenase-2 (COX-2) overexpression has been associated with a poor prognosis in many cancers. However, the role of COX-2 overexpression in head and neck cancers remains undetermined. The objective of this study was to evaluate whether COX-2 is a prognostic factor in glottic cancer. EXPERIMENTAL DESIGN This study was part of a phase III placebo-controlled randomized trial evaluati...
متن کاملPrognostic Significance of Cyclooxygenase-2 in Breast and Esophageal Carcinoma
A, Turpeenniemi-Hujanen T: Association of cyclooxygenase-2 and matrix metalloproteinase-2 expression in human breast cancer. elevated cyclooxygenase-2 expression in patients with adenocarcinoma of Lanschot JJB, Ristimäki A: Prognostic role of cyclooxygenase-2 expression in patients with squamous cell carcinoma of the esophagus. Int J Cancer, in press. The original publications are reprinted wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Veterinary Research
سال: 2019
ISSN: 2450-8608
DOI: 10.2478/jvetres-2019-0030